The show's humor turns on cultural references that cover a wide spectrum of society so that viewers from all generations can enjoy the show. Such references, for example, come from movies, television, music, literature, science, and history.
Gamera has been referenced in the show on two episodes.
- "Lisa on Ice" - In this episode, one of the characters Lisa Simpson has a dream of going to Monster Island and there Mothra, Rodan and Gamera chase and attack her.
- "Thirty Minutes Over Tokyo" - In this episode, the Simpson family are on a vacation in Tokyo, Japan, when they leave on the airplane to go home, they are attacked by Mothra, Rodan, Godzilla and Gamera.
- "Treehouse of Horror XXVI"" - in this episode Comic Book Guy watches a movie called 'Zilla' where a half Homer Simpson half Godzilla fights Gamera.